Predictors and Outcome of Acute Kidney Injury in Children with Diabetic Ketoacidosis

ABSTRACT

Objective: To identify predictors and outcome of acute kidney injury (AKI) in children withdiabetic ketoacidosis (DKA) admitted to a Pediatric Intensive Care Unit (PICU). Methods:Retrospective case review of 79 children with DKA admitted between 2011-2014. Results: 28children developed AKI during the hospital stay; 20 (71.4%) recovered with hydration alone.Serum chloride at 24 hours was independently associated with AKI. Children with AKI hadprolonged acidosis, longer PICU stay, and higher mortality. Conclusions: Majority of childrenwith AKI and DKA recover with hydration. Hyperchloremia at 24 hours had independentassociation with AKI, although cause-effect relation could not be ascertained.