Effect of Vitamin D and Calcium Supplementation on Bone Mineral Content in Children with Thalassemia
Indian Pediatr
;
2019 Apr; 56(4): 307-310
Article
| IMSEAR
| ID: sea-199309
ABSTRACT
Objective:
To evaluate the effect of vitamin D and calcium supplementation forosteoprotection in thalassemia.Methods:
29 children (age 2-12 y) were supplementedwith oral vitamin D (1000 IU/d) and calcium (500 mg/d) for 1 year. The dual energy X-rayabsorptiometry (DXA) was done to assess bone mineral content at baseline and 12 months.Serum 25-hydroxy vitamin D, intact parathyroid hormone, osteocalcin, calcium, phosphate,alkaline phosphatase, and spot urine deoxypyridinoline (DPD)/creatinine were done atbaseline, 6 months and 12 months.Results:
The mean (SD) bone mineral content increasedfrom baseline value of 8.4 (2.8) g to 10.8 (3.5) g (P<0.001). The mean (SD) vitamin D levelincreased from baseline value of 16.0 (5.8) ng/mL to 23.4 (6.6) ng/mL (P<0.001). Thechange in serum osteocalcin and spot urine DPD/creatinine ratio were not significant(P=0.062).Conclusions:
Oral vitamin D and calcium supplementation increases bonemineral content in children with thalassemia
Full text:
Available
Index:
IMSEAR (South-East Asia)
Journal:
Indian Pediatr
Year:
2019
Type:
Article
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