Effect of Vitamin E on oxidative stress and outcome of treatment in patients of anxiety disorder

ABSTRACT

Background: The purpose of present study was to assess effect of Vitamin E administration on oxidative stress and outcome of treatment of anxiety disorder.Methods: 80 newly diagnosed patients of anxiety disorder of age 20 to 60 years were included in the study. They were divided in to two groups containing 40 patients in each group. Group-I patients were given treatment with Tablet Clonazepam 0.5mg orally daily at night for six months. Group-II patients were treated with Tablet Clonazepam 0.5mgand Capsule Vitamin E 400 mg twice a day for 6 months. Levels of Mean MDA, SOD and anxiety score were assessed monthly for six months.Results: Group-I (N=38) patients treated with Tablet Clonazepam 0.5mg orally at night show significant increase in Oxidative stress. Mean MDA- 18.80�37 increased to 27.97�81, SOD- 0.143�004 decreased to 0.111�004 and decrease in mean anxiety score from first month 12.44�24 to last month of treatment 2.55�72. In group-II patients(N=37) treated with Clonazepam and Vitamin E there was decrease in mean MDA levels from 18.78�45 to 12.56�54 and increase in mean SOD levels from 0.141�007 to 0.180�000. There was reduced anxiety score in group-I from 12.44�24 to 2.55�72 and in group II from 12.54�26 to 1.86�58 which was statistically significant. p value <0.05.Conclusions: Treatment of patients treated with Clonazepam showed a significant increase in oxidative stress. In patients treated with Clonazepam and Vitamin E there was more reduction in overall oxidative stress and anxiety.