Comparison Of Racemic Bupivacaine And Levobupivacaine; Combined With Low Dose Fentanyl, Through Intrathecal Route For Transurethral Resection Of Prostate

ABSTRACT

Background and Objectives: Bupivacaine is available as a racemic mixture of dextro and levobupivacaine. Many studies show that dextrobupivacaine has greater cardiovascular and central nervous system toxicity than levobupiva-caine. The objectives of the present study were to compare the effects of racemic Bupivacaine + Fentanyl and Levo-bupivacaine + Fentanyl on the complete regression of motor block, onset time to reach T10level sensory block, dura-tion of T10level sensory block, onset time of motor block, duration of sensory block. Materials and Method: The study was conducted in 100 patients undergoing transurethral resection of prostate operation, who received either 1.75 ml Bupivacaine (0.5%) + 25 μg Fentanyl (Gr A) or 1.75 ml Levobupivacaine (0.5%) + 25 μg Fentanyl (Gr B) in-trathecally. Results: Time to complete regression of motor block, onset time toT10level sensory block were signifi-cantly prolonged in Gr A compared to Gr B. The onset time of motor block was significantly shorter in Gr A compared to Gr B. There was no statistically significant difference between the two groups in respect to the duration of T10level sensory block, duration of sensory block. Conclusion: Intrathecal Levobupivacaine + Fentanyl used in the present study can be considered as a suitable alternative to Bupivacaine + Fentanyl for spinal anaesthesia in elective TURP surgery