A Study of Serum Uric Acid Levels in Type 2 Diabetes Mellitus Subjects: A Cross Sectional Study

ABSTRACT

Introduction: Diabetes mellitus is one of the major noncommunicable diseases of which world is experiencing aserious epidemic these recent years. Uric acid serves as anearly indicator of renal complications in diabetes mellituspatients.Material and methods: This was an Observational,descriptive cross sectional study which was conducted duringa period of 18 months (October 2016 and March 2018) Thisstudy was designed to check the levels of serum uric acidand its relation with creatinine, microalbuminuria, HbA1c,fasting and post prandial blood sugar levels in type 2 Diabetessubjects.Results: Study included a total of 120 cases of type 2 Diabetesmellitus, out of which there were 69 males (57.5%) and 51females (42.5%), with a mean age of 59.04 ±13.47 years.Mean FBS was 186.10 ±77.53 mg/dl, with majority of thesubjects having elevated FBS. Mean PPBS of 274.94 ±108.66mg/dl and of HbA1c 8.15 ± 1.7 was observed. The uric acidof majority number of our study participant males (65.22%)had level of ≥ 7.4, with a mean of 9.53 ± 4.38. Mean bloodurea and serum creatinine levels were 46.91 ± 15.13 and 1.44± 0.29 respectively. There was significant association seenbetween uric acid levels and urine albumin, serum creatinine,twenty four hour urinary albumin, FBS and PPBS levels andHbA1c levels.Conclusion: Present study had about two-third subjects withtype 2 Diabetes mellitus with elevated uric acid levels hadmicroalbuminuria and elevated serum creatinine levels.