A Comparative Study of Intra Lesional Triamcinolone Acetonide alone and Triamcinolone Acetonide Combined with 5-Flourouracil in the Treatment of Keloids

ABSTRACT

Introduction: Keloids are an excessive proliferation ofdermal fibroblasts, spontaneously or following a skin injury,and are difficult to treat. Inspite of different modalities oftreatment available, effective management of keloids is adistant dream. Study objective was to compare the use ofintralesional triamcinolone acetonide and its combination with5- fluorouracil in the treatment of keloid in terms of reductionin initial height of the scar.Materials and methods: The randomised controlled trialwas conducted at the Department of Dermatology Venerologyand Leprosy, Osmania General Hospital, Hyderabad, fromNovember 2017 to April 2018. It comprised patients of bothgenders having keloids (1cm to 5cm in size) with no history oftreatment in preceding 6 months.Those who were pregnant, planning pregnancy or lactatingwere excluded from the study. The subjects were divided intotwo groups Group A received intralesional triamcinoloneacetonide alone; and Group B received triamcinoloneacetonide + 5-flourouracil. Eight injections were given at3 weekly interval. Scars were assessed 4 weeks after thecompletion of treatment on a five-point scale. SPSS 16 wasused for statistical analysis Results: The 80 subjects in the study were divided into twoequal groups of 40(50%) each. Good to excellent results wereseen in 27(67.5%) cases in Group A compared to 34(85%) inGroup B.Conclusion: Combination of triamcinolone acetonide and5-flourouracil is superior to triamcinolone acetonide therapyin the treatment of keloids.