Hemodynamic Response and Dose Requirement during Induction and Intubation with Propofol and Pentothal Sodium in Patients Undergoing Elective Coronary Artery Bypass Surgery

ABSTRACT

Introduction: The aim of the study was to observehaemodynamic changes during induction of patientsundergoing CABG with Propofol and Pentothal. It was alsointended to see if fixed dose combination of premedicationwith midazolam and fentanyl helps to reduce dose requirementof induction agents.Material Methods: 60 ASA grade II patients posted forelective Coronary Artery Bypass Surgery (CABG) weredivided into two groups. Group I (propofol group) and groupII (pentothal Group). All patients received premedication asInj.Midazolam 0.03 mg/kg and Inj.Fentanyl 4 µg/kg. Withcomputer generated randomization patient was allotted toeither propofol or Pentothal group. End point of inductiontaken as loss of eye-lash reflex or apnoea whichever appearsfirst. Hemodynamic parameters were recorded from baselinetill 7 minutes post intubation.Results: In both the groups SBP, DPB, MAP, HR and RPPwere found to be comparable. Both the drugs showed stablehemodynamic at various levels of observations. The meandose required for induction was found to be 1.7 mg/kg withpropofol and 1.07 mg/kg with Pentothal.Conclusion: Both propofol and Pentothal are equally ableto provide required stability even when standard doses ofbenzodiazepines and opioids are used in much lower dosesthan mentioned in literature