Serum Lipid Profile of Gastric Cancer Patients in Mountainous Valley of Kashmir

ABSTRACT

Introduction: Worldwide, cancer has become a public healthproblem and one of the leading causes of death. Gastric cancerdevelops in stomach and may spread to other parts of the body,particularly the liver, lungs, bones, lining of the abdomen andlymph nodes. Kashmir is a high prevalence zone of stomachcancer. Incidence of gastric cancer in Kashmir has beenreported to exceed 40% of all cancers and the incidence is 3 to6 times higher than that at various metropolis cancer registriesin India. Hence, the aim of the present study was to assess theserum lipid levels of the gastric cancer patients in Kashmir.Material and Methods: This study was conducted inDepartment of Biochemistry Govt. Medical College, Srinagaron sixty patients diagnosed with gastric carcinoma andadmitted in Shri. Maharaja Hari Singh Hospital. Venous bloodsamples were collected in green top tubes and were transportedto the laboratory and the samples were centrifuged at 3000rpm for 10 minutes and serum was separated for the estimationof Lipid profile. Each sample was processed on the sameday of its collection and was analyzed for total cholesterol,triglycerides, HDL-Cholesterol and LDL-Cholesterol.Results: The mean total cholesterol, triglyceride, HDLCholesterol and LDL-Cholesterol levels were found to be157.14 mg/dl, 136.85 mg/dl, 38.96 mg/dl and 91.52 mg/dlrespectively. The level of total cholesterol ranged from 90 to212 mg/dl while the level of triglyceride ranges between 77 to291 mg/dl and that of HDL-Cholesterol from 28 to 70mg/dland LDL-Cholesterol from 35-140 mg/dl.Conclusion: The serum triglycerides, total cholesterol andLDL-cholesterol levels fall in the normal reference range ingastric cancer patients while the mean HDL-cholesterol levelis slightly lower than the normal reference range.