Utility of Anti-Helicobacter pylori IgG Estimation in the Diagnosis of Acid Peptic Diseases: A Comparison of Serum IgG Level with Rapid Urease Test

ABSTRACT

Introduction: The mode of treatment of APD is changedradically ever since the role of H.pylori is proved for thiscondition. The study was aimed to detect the utility of antiH.pylori IgG estimation in the diagnosis of acid pepticdiseases.Material and methods: Endoscopic examination of stomachfollowed by Rapid Urease Test on the biopsy material andthe anti-Helicobacter pylori IgG quantitative estimation weredone in 85 patients with history suggestive of acid pepticdisease.Results: 46 (100%) patients with gastritis showed positiveRapid Urease Test within 30 minutes and had serum IgG >30IU/ml. 10 patients with peptic ulcer, 12 patients with non ulcerdyspepsia and 2 patients with carcinoma stomach gave positiveRapid Urease Test after 30minutes and serum IgG level was< 30 IU/ml for these patients. Of the 70 Rapid Urease Testpositive in the study, 2 of the 12 non ulcer dyspepsia patientswere negative for antibody. Endoscopy findings in 15 subjectswere normal and negative for Rapid Urease Test and antiHelicobacter pylori IgG antibody.Conclusion: Estimation of Serum anti-Helicobacter pyloriIgG may be useful as a non invasive method in the diagnosisof gastritis.