Clinical Evaluation of Maternally Inherited Type-2 Diabetes and Deafness in a Tertiary Care Hospital at Puducherry

ABSTRACT

Introduction: Maternally Inherited Diabetes and Deafness(MIDD), a specific clinical syndrome results in sensory neuralhearing defect in diabetes population which may lead toA3243G mutation in tRNALeu (UUR) gene.Materials and methods: A prospective case control study, thenon probability convenient sampling technique was followedin this study. The subjects were divided into non diabetic anddiabetic with maternal inheritance groups. Hundred patientswith the strong maternal history of diabetes is group 1 andhundred non diabetic individuals with no maternal history ofdiabetes is group 2. Blood and urine samples were collectedand analyzed biochemical parameters among the two groups.In addition, audiometric analysis was also carried out for thosegroups.Results: The mean age of onset of diabetes was 41 yearsand deafness was 51 years. The mean plasma glucose,Glycosylated Hemoglobin(HbA1C), Serum Insulin, InsulinResistance, Cholesterol, Triacyl glycerides, Very Low DensityLipoprotein(VLDL), Low Density Lipoprotein, SerumUrea, Serum Uric acid, Serum Creatinine and Albumin toCreatinine Ratio (ACR) levels in patients were significantlyhigher whereas High Density Lipoproteins(HDL) and urinecreatinine levels were significantly low as compared withcontrols. The mean Body Mass Index (BMI) is slightly higherin patients as compared with control group.Conclusion: The study helps us to understand that theMaternally Inherited Diabetes and Deafness syndromeseverely alters the insulin resistance level, ACR ratio and lipidprofile which may lead to multiple organ disorder at early ageof diabetes.