Study of Vit D Supplementation in Type 2 Diabetes Mellitus

ABSTRACT

Introduction: Vitamin D deficiency is being evaluated asimportant risk factor in development of insulin resistance andVitamin D supplementation may be beneficial in managementof type 2 DM. A pre-post Intervention study in a tertiary carehospital was conducted to observe the effect of Vitamin Dsupplementation in glycemic control and insulin resistance inType 2 Diabetes Mellitus.Material and Methods: Estimation of Fasting and postprandial plasma sugar, 25 hydroxy Vitamin D, serum fastinginsulin and Insulin resistance, calculated using Homeostaticmodel assessment of Insulin resistance (HOMA-IR) method,in 300 known cases of Type2 Diabetes Mellitus and 50 age andsex matched healthy controls was done. Oral supplementationof Vit D, 60,000IU/week for 4 weeks was given to the group ofDiabetics with decreased vit D level <20 ng/ml. Fasting seruminsulin and Vit D level was repeated after 7 days of 4th doseof vit D supplementation. The pre and post supplementationvalues of Fasting serum Insulin, vitamin D levels and Bloodsugar levels were recorded and statistically analysed.Results: The prevalence of vitamin D deficiency (< 20 ng/mL). in type II diabetics was 30%. Comparison of parametersafter supplementation to the Vit D deficient Diabetic group,revealed a significant decrease in Fasting plasma glucose (pvalue 0.0028) with no significant change in the mean baseline2 h plasma glucose or HbA1c. There is a statistically significantdecrease in Fasting serum insulin levels (p <0.0031) anddecrease in insulin resistance (p=<0.0001) after 4 weeks ofVit D supplementation.Conclusion: Supplementation of Vit D results in decreasingthe insulin levels and insulin resistance in the Vitamin Ddeficient type 2 diabetics in Indian population. VitaminD supplementation in Diabetics could be beneficial inmanagement of Type 2 DM.