Study of Correlation Between Mid Trimester Serum Beta Human Chorionic Gonadotropin Levels and Prediction of Hypertensive Disorders of Pregnancy

ABSTRACT

Introduction: Hypertensive disorders of pregnancy (HDP)are among the commonest medical disorders during pregnancyconstituting one of the greatest causes of maternal and perinatalmorbidity and mortality worldwide. In view of increasedmaternal and foetal morbidity and mortality associated withHDP and lack of definite predictive test for early identificationof the woman at the risk of HDP, this study was undertaken tocorrelate the raised serum beta hCG measured in early secondtrimester with prediction of HDP.Material and Methods: The study group consisted of A totalof 150 pregnant women attending Maharaja Agrasen hospitalOPD/IPD during their second trimester (14-20 weeks) ofpregnancy from Dec 2016 to Nov 2017.Results: Out of 146 cases studied, 129 cases remainednormotensive and 17 cases developed HDP. Out of 17 cases,8 cases had mild HDPs and 9 cases had severe HDPs. Weobserved that serum β hCG levels for those women (GroupA) who developed HDPs were significantly higher thannormotensive group (B). By using β hCG value of 2 MoM asa cut off, its sensitivity as a screening test for HDP was 58.8%,the specificity was 96.9%, and the positive and negativepredictive values were 71.43% and 94.70 respectively.Conclusion: My study showed that raised mid trimesterserum β hCG value can be used for prediction of Hypertensivedisorder of pregnancy before its clinical outset as well asdrawing special attention and care of cases having raised βhCG value from initial phase to prevent both maternal andfetal morbidity and mortality resulting from HDP. Our studyalso revealed correlation between raised mid trimester serumβ HCG value and severity of HDP.