A Study of Changes in Lipid Profile among Pre-diabetics and Diabetics in Population of Lucknow

ABSTRACT

Introduction: Cardio vascular disease (CVD) is the leadingcause of mortality and morbidity in diabetes mellitus (DM)contributing to 65% of all deaths with diabetic complications.Detection of the deranged lipid profile in the pre-diabeticstate has been shown to be associated with increased risk ofatherosclerosis. This study was planned to compare changesin lipid profiles of patients with pre-diabetes and diabetes inpopulation of Lucknow, India.Material and Methods: A total of 236 cases (115 Pre-diabeticand 121 Diabetic) who fulfilled the inclusion and exclusioncriteria of this study were enrolled. The patients were evaluatedfor serum fasting blood sugar (FBS), post prandial blood sugar(PPBS), HbA1c, total cholesterol (TC), triglycerides (TGs), inthe two groups. The results were statistically analysed usingSPSS statistical package version 20.Results: The mean value of total cholesterol were179.21±8.12mg/dl in pre-diabetics and 182.31±7.99mg/dl indiabetics, which was statistically not significant (p=0.003).The mean value of triglyceride in pre-diabetics was134.43±5.21mg/dl and in diabetics 167.87±7.37mg/dl whichis statistically significant (p<0.001).Conclusion: The altered lipid profile in pre-diabetics signifiesan increased susceptibility to CVD in the long run. Therefore,screening of pre-diabetics for dyslipidemia is recommendedto arrest the development of cardiovascular complications.