IL-12 Levels in Pregnancies with Preeclampsia and Periodontitis

ABSTRACT

Introduction: Periodontal pathology has become amomentous concern of public health due to its increasingprevalence in adults around the globe. Study was aimed tocompare serum IL-12 p-70 levels in preeclampted and nonpreeclamptic women and to observe serum IL-12 p-70 levelsin preeclamptic with and without chronic periodontitis.Material and methods: It was a Longitudinal Cohort Study.The sampled population belonged to Narowal District ofPunjab, Pakistan. Duration of the study was from June 2016to February 2018. All pregnant subjects’ aged in-between18-34 years were participated though convenience samplingand consented. Out of total 73 subjects, 33 were with healthyperiodontium (6 preeclamptic and 27 normotensives) and40 were with chronic periodontitis (6 preeclamptics and 34normotensives). Sampling was performed in two phases; Firstwhen all subjects were in 2nd trimester and second when allwere in postpartum period. Periodontal status was assessed byCPITN (Community Periodontal Index for Treatment Need)probing technique and for preeclampsia, monthly bloodpressure profile of each participant was taken by her doctor.Serum estimation of IL-12 p-70 was confirmed throughsandwich ELIZA technique. Microsoft Excel and Minitabwere used for data analysis.Results: Normotensives with healthy periodontium showed17.4% high serum IL-12 p70 (pg/ml) in antepartum thanpostpartum. Similarly preeclamptics with healthy periodontiumexhibited 13.4% high serum IL-12 p70 in antepartum thanpostpartum. While normotensives with periodontitis displayed10% high serum IL-12 p70 in postpartum than antepartum.Preeclamptics with periodontitis exhibited 17.4% high serumIL-12 p70 in postpartum than antepartum.Conclusion: Preeclampsia and chronic periodontitisboth decrease serum IL-12 p-70 levels in antepartum andpuerperium.