Coagulation Profile and Platelet Indices in Diabetes with Chronic Kidney Disease on Haemodialysis

ABSTRACT

Introduction: Bleeding and thrombotic complications arehigh possibility in CKD. The present study was conductedto evaluate the platelets indices in patients on haemodialysishaving Type 2 diabetes with CKD as compared to diabeticpatients without CKD.Material and methods: 100 patients of ckd with diabetesand 100 patients of diabetes without ckd were studied over aperiod of seven months. The coagulation profile and plateletindices were compared. The coagulation profile and plateletindices were also compared in ckd patients before and afterdialysis.Results: Increase in platelet indices mainly MPV and PlateletDistribution Width (PDW) with significant p-value 0.003 and0.005 respectively in study group. PT and APTT both wereincreased in study group with significant p-value of 0.003.Platelet count improved but MPV and PDW values wereslightly decreased with p-value < 0.005. PT showed not muchdifference whereas APTT values were higher compare to postdialysis with p-value<0.007.Conclusion: Basic coagulation profile like PT and APTT andMPV can predict long term complications of diabetic plateletson haemodialysis and these should be monitored in CKDpatients.