Association of Squamous Cell Carcinoma with Nonfunctioning Kidney due to Renal Stone Disease

ABSTRACT

Introduction: Sqamous cell carcinoma accounts for 0.5-0.8%of all renal tumour. Squamous cell carcinoma (SCC) of therenal pelvis is a rare neoplasm and is usually associated withlong standing renal stone disease. There is lack of definiteclinical presentation and inconclusive imaging finding, thesetumors are high grade, highly aggressive with poor prognosis.Histopathology report is hallmark for diagnosis.Material and methods: Our study is Retrospective studywith sample size of 5 patient (3 male and 2 female), presentingcomplaints of all patients had a chronic history of renal stonedisease with loin pain presented during last 2 year of period inUrology department. All patient were evaluated with routinepreoperative blood investigation, DTPA renogram, and NCCT(KUB), found to have nonfunctioning kidney underwentsimple nephrectomy.Result: In our study mean age is 52 year, 3 male and 2 female,mean operative time- 2hr,during postoperative period 3patient have uneventful postoperative course,1 patient haveatrial fibrillation,1 patient have a suture site infection, averagehospital stay 4.5 days. Postoperative histopathology reportconfirmed presence of squamous cell carcinoma, 3 patient onregular follow up with no evidence of recurrence, 1 patientdies during follow up and 1 patient lost follow up.Conclusion: Primary squamous cell carcinoma of kidney arerare aggressive tumour with poor prognosis. As this tumor isassociated with renal stone and non functioning kidney, theyshould be evaluated with newer imaging technology for earlydetection of tumour.