Oncocytic Carcinoma of Parotid Gland: A Case Report

ABSTRACT

Introduction: Oncocytic carcinoma (OC) of salivary glandorigin is an extremely rare proliferation of malignant oncocyteswith adenocarcinomatous architectural phenotypes, includinginfiltrative qualities. To help clarify the clinicopathologicfeature of this tumor group, herein, we report a case ofoncocytic carcinoma arising from the salivary glands, togetherwith radiological and immunohistochemical observations.Case report The tumor was reported in the parotid regionof a 50 year old female. The tumors were unencapsulatedand was seen invading into the nearby lymphatic tissues. Theneoplastic cells had eosinophilic granular cytoplasm and roundvesicular nuclei with prominent red nucleoli. Cellular atypiaand pleomorphism was mild. Immunohistochemistry reveleadDOG1 and p63 positivity. In summary, OC of salivary glandorigin is a high-grade tumor, often with local recurrence,regional or distant metastasis, diagnosis of which is based ona combination of clinical and histopathological features.Conclusion: Complete surgical excision is the treatment ofchoice while the role of radiotherapy or chemotherapy iscontroversial, and careful follow-up is necessary.