Carotid Intimal Medial Thickness (CIMT) in Patients of Chronic Kidney Disease (CKD) and its Association with CKD Staging

ABSTRACT

Introduction: Association between Chronic kidney disease(CKD) and increased risk of cardiovascular disease (CVD)is well established. Relationships of carotid intima-mediathickness (CIMT) as a measure of subclinical atherosclerosisin CKD patients is a matter of debate. Current research aimedto study the role of CIMT in CKD patients and its associationwith the CKD staging.Material and Methods: Hundred CKD patients werestudied and compared with 50 subjects without CKD in theDepartment of Medicine, G.R. Medical College & J.A. Groupof Hospitals, Gwalior (M.P.) India. GFR was determined byMDRD (Modification of diet in renal study) equation. Studypopulations were subjected for high resolution B - modeCarotid ultrasonography.Results: In case group, majority were males (68%) havingage between 30-60 years (62%). Majority had stage V CKD(67%), 21% had stage III and 14% had stage IV CKD.Majority of the cases had CIMT between 0.9-1.0 mm (42%)followed by 0.7-0.8 mm (17%) as compared to 0.5-0.6 mm(42%) in control. Mean CIMT was significantly higher incases (0.87±0.24) as compared to control (0.61±0.34) group(p<0.001). No significant difference in mean CIMT was foundbetween different stages of CKD (p=0.649).Conclusion: CKD patients have significantly more carotidarterial wall thickness in comparison to age matched controls.The CIMT does not differ in different stages of CKD.