A Study on Diabetes and Parkinson’s Disease in a Tertiary Care Centre at Central Tamilnadu

ABSTRACT

Introduction: Parkinson’s disease (PD) is one of the chronicneurodegenerative disorder and is the most common cause ofparkinsonism, which is a syndrome manifested by rest tremor,rigidity, bradykinesia, and postural instability. Diabeteswhether is a risk factor for developing PD is a question oftenraised for many years and to date there are conflicting data onassociation of diabetes and Parkinson’s disease. Study aimedto study the effect of glycemic status on Idiopathic Parkinson’sdisease (PD) and to identify the modifiable and non modifiablerisk factors in idiopathic Parkinson’s disease (PD).Material and methods: Consecutive patients with adiagnosis of idiopathic parkinson’s disease(PD) satisfyingUK Parkinson’s disease society brain bank clinical diagnosticcriteria attending the department of neurology during theperiod January 2019 to December 2019 were included in thestudy. Study design was a cross sectional, observational study.Results: Total of 70 patients were enrolled in the study. Tremorwas the most common motor symptom. 53.3% of subjects hadone or the other non motor symptoms. Diabetes was presentin 38.6% of subjects. Mean FBS among the cases was 112.36% of the subjects had poor control of diabetes based ontheir HbA1C values (HbA1C >7). There was statisticallysignificant relation between glycemic control and clinicalstage of PD with a P value <0.05.Conclusion: Prevalence of diabetes in PD is significantlyhigher compared to general population statistics. PD patientshad favourable lipid parameters. Poor glycemic control amongPD with diabetes had statistically significant relationship withclinical stage.