Spectrum of Microorganisms Causing Blood Stream Infection and the Antibiotic Sensitivity Pattern among Gram Negative Organisms: A Study from a Tertiary Care Centre in Bihar

ABSTRACT

Introduction: Incidence of Blood stream infection (BSI) is onthe rise and so is the increasing drug resistance amongdifferent organisms causing BSI. The trend of such infectionand the antibiotic sensitivity pattern may vary from region toregion.Materials and Methods: This study was conducted with thesame aim in which about 240 blood culture and sensitivityresults were noted from the records and were analysed to seethe current trend in this region. Our focus was mainly on Gramnegative organisms, as they have been found to causeincreased number of BSI.Results: Escherichia coli was the main Gram negativeorganism, and Staphylococcus aureus along with Coagulasenegative Staphylococcus (CoNS) were the main gram positiveorganisms isolated. Candida albicans was also found in four ofthe cases. The antibiotic sensitivity pattern of gram negativeisolates showed more than 90% susceptibility to higherantibiotics, whereas the susceptibility to other antibiotics werefound to be variable.Conclusion: E. coli is the main GNB causing the infectionfollowed by K. pneumoniae and P. aeruginosa. Increasingtrend of drug resistance is being noted by GNBs against mostcommonly used antibiotics.