To Assess the Safety and Efficacy of Misoprostol Administered Vaginally For Induction of Labour in Patient with PROM with Poor Bishop’s Score

ABSTRACT

Background: The management of PROM has often been adilemma in obstetrics. This study is aimed to assess the safetyand efficacy of misoprostol administered vaginally for inductionof labour in patient with PROM with poor Bishop’s Score.Materials & Methods: A randomised observational study doneon 90 Patients of PROM admitted in labour room of MahilaChikitsalaya, SMS Medical College, Jaipur as per inclusion andexclusion criteria. Augmentation with oxytocin was done inpatients with favourable bishop score (>5) with mild uterinecontraction or patients with poor bishops score (<5) even after3 doses of misoprostol. If leaking of more than 24 hours andunfavourable cervix (bishop <5) or any evidence of foetaldistress then further management was at the discretion ofattending obstetrician.Results: Our study showed that the mean induction deliveryinterval was 7.67±4.86hours & 78 patients (86.7%) deliveredwithin 12 hours after induction in patient of PROM. Apgar scoreof new born babies at 1 min in majority was 8 – 10 min.(81.1%) and at 5 min in majority was 8-10 (98.9%).Conclusion: Misoprostol maximum of 75µg is an effectivemethod of improving the inducibility score and induction oflabour in properly selected cases. Misoprostol in above dosesis without any untoward effect on maternal and foetal outcomeand hence, safe.