A Study to Know the Effect of Antiepileptic Drugs on Liver Enzymes

ABSTRACT

Objective: To know the effect of antiepileptic drugs on liverenzymes.Study Design: Cross sectional study.Materials & Methods: The study was conducted on 108patients at SIMS Hapur and G.S Medical College Hapurbetween Jan 17 to Dec 17. Patients divided into 3 groups,consisting of 36 patients in each group of phenytoin,carbamazepine and valproate.Results: Total No. of Patients was 108, out of which 36patients were there is each group of Phenytoin,Carbamazepine and valproate. Most of the patients 36(33.33%) and 32 (29.62%) belongs to age group of >40 – 50years and >50 year respectively. Regarding raised SGPT, itwas seen in 5 (13.89), 3 (8.33) and 3 (8.33) in phenytoin,carbamazepine and sodium valproate group respectively.SGOT were raised in sodium valproate group respectively.Alkaline phosphatase were raised in 10 (27.78), 20 (55.56) and22 (61.11) in phenytoin group, carbamazepine group, andsodium valproate group respectively.Conclusion: From the present study we can conclude thatsodium valproate is more hepatotoxic than carbamazepinewhich is more toxic than phenytoin. It is recommended thatbase line Liver Function Test (LFT) is essential before startingof AEDs and regular monitoring of LFT is also done betweenthe course of treatment.