Cardiopulmonary Efficacy of a Single Dose of Sildenafil in Patients with Chronic Heart Failure

ABSTRACT

Back Ground Chronic Heart Failure is Associated withsecondary hypertension, impaired vascular reactivity andpermeability and reduced alveolar capillary membraneconduction. Sildenafil is a potent and selective inhibitor ofcGMP phosphodiestrase 5 which is responsible for degradationof cGMP, Stabilisation of cGMP result in increasing NO at thetissue level leading to pulmonary vessel vasodilatation.Methods: This study was conducted in Benha UniversityHospital, it included 30 patients with chronic heart failure, theywere divided into two groups, Group (1) was the control groupconsisted of 15 patients and received the standard therapy,Group (2) was the active group consisted of 15 patientsreceived single dose of Sildenafil 50 mg in addition to standardtherapy.Results: In current Study the mean pulmonary artery systolicpressure (PASP) before giving Sildenafil was 58.4 mmhg andafter two hours of use Sildenafil it became 51.7 mmhg. AlsoSildenafil caused significant improvement of peak minuteventilation (VE), peak oxygen uptake (VO2), peak carbondioxide output (VCO2).Conclusion: So Sildenafil is Safe in Stable congestive heartfailure as it reduces pulmonary hypertension, improve exercise