Effect of Serum IgE Level between Frequent Relapse and Infrequent Relapse Nephrotic Syndrome in Children

ABSTRACT

Objective: In this study our main objective is to evaluate effectof serum IgE level between frequent relapse and infrequentrelapse nephrotic syndrome in children.Methodology: This Cross-sectional comparative studyconducted at the Department of Paediatric Nephrology,Bangabandhu Sheikh Mujib Medical University (BSMMU) andDepartment of Paediatrics, Dhaka Medical College Hospital,Dhaka from February 1, 2010 to October 1, 2010. During thestudy, 60 children were included in the study according tojudgmental or purposive sampling method and they weregrouped as follows Group A (n = 30) Frequent RelapseNephrotic Syndrome (FRNS), Group B (n= 30) InfrequentRelapse Nephrotic Syndrome (IFRNS).Results: During the study, majority (60%) were of age groupA, 2-5. On the other hand in group-B, majority (66.8%) were ofage groups 2-5 years followed by (16.7%) were of age group 6-9 years and 5 (16.6%) were of age group 10-15 years. Duringrelapse of the disease serum immunoglobulin E (IgE) level wasapproximately 3.5 times higher in group A than that of group Bwhich was 1573.60IU/ml (SD ±197.01) vs. 438.46IU/ml (SD±51.6).Conclusion: From our study we can conclude that, that serumIgE level in frequent relapse nephrotic syndrome wassignificantly higher (P < 0.001) in comparison to infrequentrelapse nephrotic syndrome in children during both relapse andremission irrespective of history of atopy. So serum IgE levelmight have an influence for the occurrence of relapse inchildhood idiopathic nephrotic syndrome