Efficacy of Propofol and Etomidate for General Anaesthesia: A Comparative Study

ABSTRACT

Background: Induction agents are given to induce anesthesiaprior to the drugs given for maintenance of anesthesia, whichare also used as the sole drug for short treatment procedures,to give conscious sedation while undergoing procedures underlocal anesthesia and intensive care unit. The present studywas conducted with the aim to determine the compare theefficacy of propofol versus etomidate.Materials and Methods: This prospective randomized studywas conducted amongst 200 patients belonging to (ASA) gradeI and II between the age of 18 and 60 years irrespective of thegender who were scheduled for surgical procedure under thegeneral anesthesia. Pain on injection was graded On a 4graded scale with 0 meaning no Pain and 3 meaning bothverbal complaint and withdrawal of arm. All the data thusobtained was recorded in a tabulated form and analyzed usingSPSS software.Results: The study enrolled a total of 200 subjects with themean age of 41.78+/-3.94 years. There were 120 males and80 females in the study. There were 100 patients in eachgroup. All the subjects in Group I had grade 0 myoclonus.There were 65 patients in Group II with Grade 0 myoclonus, 15with grade 1 and grade 2 myoclonus respectively and 5 withGrade 3 myoclonus.Conclusion: Etomidate is a better anesthetic compared topropofol. It offers great hemodynamic stability with better paincontrol.