The Blood Glucose Lowering Effect of Aqueous Extract of EmblicaOfficinalis Fruits in Alloxan Induced Hyperglycemic Rats

ABSTRACT

Background: Diabetes mellitus which is a chronic metabolicdisorder categorized by elevated blood glucose levels anddisturbances in carbohydrate, fat and protein metabolism.Objective: In this study our main goal is to evaluate the bloodglucose lowering effect of aqueous extract of Emblica officinalisfruit in alloxan induced hyperglycemic rat.Method: The aqueous extract was orally administered for 4weeks at a dose of 250mg/kg b.w, 500mg/kg b.w. Weeklyestimates of fasting blood glucose level were recorded innormal non-diabetic rats as well as in alloxan induced diabeticrats.Results: Aqueous extract of Emblica officinalis fruit showed noblood glucose lowering activity in non-diabetic rats. But therewas a significant reduction in blood glucose level (p<0.001),when compared with diabetic control. Similar results werefound when compared with a standard anti-diabetic drug,glibenclamide at a dose of 5mg/kg b.w. Aquouse extract500mg/b.w produce the maximum response in reducing bloodsugar level of diabetic rats.Conclusion: We can conclude that, the aqueous extracts ofE.officinais produce significant change in blood glucose level,specially 500 mg/kg b.w dose on pharmacodynamics responsemay be useful in insulin resistant cases and to postpone theoccurrence of diabetic complications. Further study is neededfor better outcome.