Incidence of Seropositive But HIV-1 Viral RNA Not Detected Naive Cases In Rajasthan

ABSTRACT

Objectives: To identify cause of HIV seropositive but ViralRNA undetected naive cases in Rajasthan.Materials and Methods: This study included 250 HIV seropositive cases from ICTC Centre, SMS Jaipur .HIV Viral loadwas done by Qiagen HIV-1 viral load kit on ABI 7500 Fast dxReal Time PCR, while CD4 count was done on FACSCALIBUR flowcytometer (BD Biosciences).Results: A total of 250 HIV Serological confirmed positivesamples were tested for HIV-1 RNA viral load & CD Count inthe period of 2014-19. Out of 250, 26 (10.4%) cases werefound in which viral RNA were undetected. out of 26seropositive but HIV RNA undetected case, 16(61.5%) wereMale while 10 (38.5%) were females. Mean of CD4 in Femalewas 565 while 650 in males.Conclusion: HIV‑1 seropositive patients but undetected viralload is not uncommon in society. HIV sero-positive but viralRNA undetected males CD4 count were higher than females. Itwas also observed that all the cases of seropositive withundetected viral load had higher CD4 count comparative withseropositive with viral RNA detected patients. It is concludedthat RNA viral load test is a prognosis test, although suchpatients who had seropositive but viral load undetected needfurther investigations after 3-4 weeks to monitor the status ofthe disease