Clinical Study of Serum Uric Acid Level on Outcome of Pregnancy in Cases of Pregnancy Induced Hypertension (PIH)

ABSTRACT

Background: Hypertensive disorder is one of the commonestmedical complications of pregnancy. It is assumed that serumuric acid elevation is a specific laboratory finding for thedisease.Objectives: To assess the effect of raised Serum uric acidlevel on outcome of pregnancy in cases of PIH (PregnancyInduced Hypertension).Methods: A Prospective study was conducted to pregnantpatients (between 28-40 weeks of pregnancy with PIH). Total100 patients were selected, who were separated into twogroups. Those who had Serum uric acid level more than6mg/dl (67 participants) are classified as Group A and thosewho had Serum uric acid level less than 6mg/dl (33participants) are classified as Group B.Results: Age of PIH patients were within 16-40 years. Theserum uric acid was significantly elevated in all the patients.Concentration of Serum uric acid is much higher in Eclampsiagroups, which is 4.5-12.0 mg/100ml (7.36 ± 2.17), incomparison to Preeclampsia patients, which is 2.6-9.6mg/100ml (6.28 ± 1.64). Comparing maternal outcome withSerum uric acid level between group A and group B patients,percentage of PPH and Abruptio placenta was higher in groupA than group B. In addition, Postpartum eclampsia, HELLPsyndrome and Pulmonary oedema were present in group A(each 2 in number); but these complications are not found ingroup B. In perinatal outcome, the better consequence wasobserved in group B in case of birth weight, intrauterine growthretardation, still birth and neonatal death rate. There wasstatistical significant association between Serum uric acid andbirth weight of group A & B (p= 032).Conclusion: The degree of hyperuricemia increases with theseverity of preeclampsia. Perinatal mortality was markedlyincreased when maternal serum uric acid concentration wereraised. Serum uric acid was an important indicator for maternalcomplications and prognosis of fetus.