Study of Hematological Parameters in Plasmodium Falciparum Malaria in Tertiary Care Hospital

ABSTRACT

Background: Malaria still continue to be a major killer ofmankind especially in developing countries. Almost all deathsand severe disease are due to plasmodium falciparum. It isobserved that the patients of falciparum malaria with liver, renaland hematological abnormalities are more vulnerable todevelopment of complications like cerebral malaria, anaemia,acute respiratory distress syndrome etc.Methods: 50 cases of plasmodium falciparum malariadiagnosed by peripheral smear examination or byimmunochromatographic tests were included in the study. Allthese patients are subjected to blood investigations.Results: 68% patients were males with sex ratio MF was2.12 1. Majority of patients (26%) belong to age group of 21-30 years. Most common presentation was fever in 100% ofpatients, followed by headache in 48% of patients, vomiting in46% of patients. 18% and 14% patients having haemoglobinbetween <7 and 7-9 mg% respectively with mean haemoglobinwas 09.69+-2.95mg% with range of 2.5-15 mg%.58% patientshaving WBC count between 4000 – 11000/mm3 with mean was7074 +/-4049.48/mm3 with range of 1200-17800/mm3. 28%patients were seen having platelet count between 50001 –75000/dl and 75001-150000/dl and only 8% patients werehaving platelet count <25000/dl. Mean RBSL level was 98.3+/-23.47 mg % with range of 54 – 190 mg%. 08% patients werehaving RBSL less than 60mg%. Only 4%patients were showingderranged bleeding, clotting time and PT-INR .But none ofpatients showing bleeding diathesis. P Falciparum malaria withrenal and liver dysfunction mostly associated with coagulationabnormality with or without bleeding diathesis having badprognosis.