An Observational Study on Association of Gall Stone Disease and Iron Deficiency in the Population of Kolhan Region of Jharkhand

ABSTRACT

Background: Gallstone disease is common gastrointestinalproblem encountered in day to day practice. Super saturationof bile in cholesterol, enhanced nucleation of cholesterol,impaired gallbladder emptying and intestinal hypo motilityfavors the formation of gallstones. Consumption of diet rich incarbohydrates but deficient in iron alters hepatic metabolism ofcholesterol and promotes cholesterol crystal formation.Objective: To correlate iron deficiency anemia with gallstonedisease in Kolhan region of Jharkhand.Materials & Methods: A prospective study was conductedduring period of one year in department of surgery MahatmaGandhi Memorial Medical College Hospital, Jamshedpur. 50patients with ultrasonographically proven gallstone diseaseadmitted in surgery department during this period wereincluded in the study. 50 individuals admitted in surgerydepartment, not suffering from gall stone diseases were takenas control group. Subjects were divided into two groups anemicand non-anemic based on Hemoglobin% and serum iron.Serum cholesterol of both the groups was estimated.Results: Female was affected more in case and control groupwith mean age 39.72±15.382.Conclusion: Iron deficiency anemia plays a significant role insuper saturation of bile with cholesterol leading to gallstoneformation.