Analysis of Coagulation Disturbances in PCOS Patients at a Tertiary Care Teaching Centre

ABSTRACT

Background: The polycystic ovary syndrome (PCOS) is ahyperandrogenic disorder associated with chronic oligoanovulation and polycystic ovarian morphology. Themechanisms of potential disturbances of the hemostaticsystem in women with PCOS are unknown. Hence; presentstudy was planned to evaluate the coagulation disturbances inPCOS patients.Materials & Methods: The present study was planned toanalyse various coagulation disturbances in PCOS patients. Atotal of 20 patients (study group) and 20 healthy controls wereincluded in the present study. Blood samples were withdrawnfrom all the subjects and complete haematological profile wasobtained.Results: Mean fibrinogen profile of the subjects of the PCOSgroup and the control group were 3.65 and 2.61 g/lrespectively. Mean value of factor VIII of the subjects of thePCOS group and the control group were 1.25 and 0.98 IU/molrespectively. Significant results were obtained while comparingthe mean fibrinogen profile among the two study groups.Conclusion: Coagulation profile shows significant alterationsin patients with PCOS.