Study of Serum Osteocalcin Level as a Biomarker of Severity in Patients of NAFLD

ABSTRACT

Introduction: Osteocalcin has been considered an establishedmarker of bone formation; but the newer evidences suggestedits role in the obesity, metabolic syndrome, and type 2 diabetesmellitus. Thus, it plays an important part both in bone andenergy metabolism.Methodology: This study was conducted in the Department ofBiochemistry, Department of Pharmacology & Department ofMedicine, PMCH, Patna. Two groups were included in thisstudy. One is Non-NAFLD group and another group is NAFLD.Non-NAFLD group having 130 cases while NAFLD grouphaving 44 cases. The duration of study was over a period ofone year.Results: This study revealed that serum osteocalcin levels areinversely associated with NAFLD.Conclusion: This study conclude that, osteocalcin isconsidered as a biomarker of severity in patients of NAFLD.