One Year Therapy with Cyclosporine A is Useful in Prevention of Early Autoimmune Transformations in Predisposed Patients for Type I Diabetes Mellitus

ABSTRACT

Type 1 diabetes (T1D) is a chronic autoimmune disordercharacterized by specific immune destruction of the insulinproducing pancreatic β-cells. The loss of β cells involves bothgenetic and ill-defined environmental factors. The highest riskHLA-DR3/4 DQ8 genotype has been shown to be highlyassociated with β-cell autoimmunity and benign insulinitis.Subsequently; catalysts viz. viruses transform predisposedsubjects into overt diabetics. Such autoimmunity is herald byautoantibodies and subsequently low C-peptide production.Hence, there is no ideal autoimmune therapy for T1D sincepatients are genetically predisposed. Previous autoimmunemeasures to suppress early transformations were crippled bylong-term complications of medications. In our case report; welimited the use of Cyclosporine A to 1 year in a patient and itwas cost effective.