A Study on the Clinical and Pathological Evaluation of Dysfunctional Uterine Bleeding

ABSTRACT

Background: Abnormal uterine bleeding, a commongynecological problem is caused by a range of etiologies thatmay be functional or organic. Histo-pathological analysis ofendometrial sample is considered gold standard for the studyof endometrial pathology. Thus here we made an attempt tostudy endometrial pattern in women with AUB and correlatethat with clinical parameters.Materials and Methods: This hospital based study involved 50patients with AUB and attending Varun Arjun Medical Collegeand Rohilkhand Hospital. The patients were divided asreproductive (<40), perimenopausal (41-50) and postmenopausal group (>50). The endometrial samples wereprocessed and histopathological analysis was conducted.Result: Most of study patients were under reproductive agegroup (52.8%) and multigravid (28%). Functional abnormalitieswere the common causes of AUB (72%). Menorrhagia wasmost frequent bleeding pattern observed (36%) followed bymetrorrhagia (18%). In case of reproductive age group andperimenopausal, the common histopathological abnormalitywas proliferative endometrium (18% and 12%) while for postmenopausal age group, it was 8 %. For primipara groupdisordered proliferative endometrium (8%), for multipara groupproliferative endometrium (24%) and for grand multiparagroup endometrial hyperplasia (10%) were the most frequentlyobserved abnormalities. A single case of malignancy wasobserved in post-menopausal multipara female.Conclusion: Histopathological study of endometrial biopsyhelps the clinicians in selecting the appropriate therapeuticapproach. It is simple and cheap method hence should beused as first line strategy thus reducing the need of otherexpensive and complicated approaches.