Drug Release of Bacterial Cellulose as Antibacterial Nano Wound ‎Dressing

ABSTRACT

Bacterial cellulose (BC) is a natural polymer that can be utilized for many applications. Because of its renewable nature, goodbiocompatibility and excellent physical features of bacterial cellulose, it can be utilized in pharmaceutical, biomedical fields, andnanotechnology applications. In this study, we prepared antibiotic bacterial cellulose loaded with tetracycline hydrochloride andgentamicin, and its drug release, as well as antibacterial activity, were evaluated separately. The structure and morphology of the loadedbacterial cellulose were determined by scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR).AATCC100 test was used for antibacterial properties against Escherichia coli and Staphylococcus aureus. Ultraviolet spectrophotometrydevice was used to detect absorption and release process of mentioned antibacterial cellulose. By these unique specifications of bacterialcellulose layer loaded with tetracycline hydrochloride and gentamicin, we found that they may successfully serve as a wound dressing andother medical biomaterials.