Determination of the Stability Constants Comlexes of Metformin Hydrochloride With Cu(II), Cd(II) and Zn(II)

ABSTRACT

In the present work, binary complexes of Copper(II), Cadmium(II) and Zinc(II) with metformin hydrochloridehave been studied potentiometrically. Stability constants of binary complex systems have been estimated by themethod proposed by Irving-Rossotti at 25ºC and 0.11M ionic strength (NaClO4) in aqueous solution. Theconditional formation constants of the complexes formed between ligand and metal were calculated according topH function. The maximum values of the conditional formation constants were found to be in accordance with themixed metal-ligand complex formation constants in a given pH region. In addition to these, the molar fractionswere calculated using the formation constants of the mixed metal-ligand complexes. As a result of theexperimental study, the values of stability constants of metal-ligand complexes at 25ºCare as noted belowlogK1=8.45; logK2=8.30 for Zn(II)-Metformin hydrochloride; logK1=8.78 ; logK2=8.00 for Cu(II)-Metforminhydrochloride logK1=8.18; logK2=7.36 for Cd(II) – Metformin hydrochloride.