The Role of Fish Oil and Evening Primrose Oil against the Toxicity of Fenitrothion Pesticide in Male Rats

ABSTRACT

Pollutants in the environment and exposure to them lead to medical ailments around the world. The present studyaimed to evaluate the protective effect of evening primrose oil and fish oil against fenitrothion pesticide-inducedtoxicity in rats. Male Wistar rats weighing 150-220 g, were randomly distributed into seven groups, the firstserved as control. The second group received fenitrothion, the third and fourth groups were supplemented withfish oil and evening primrose oil, respectively. Rats of group five were exposed to fish oil and fenitrothion. Thesixth group was exposed to evening primrose oil and fenitrothion. Rats of the seventh group were exposed to fishoil and evening primrose oil and fenitrothion. The results showed that the activities of serum alanineaminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), and the levels of bilirubin (BIL), total protein (TP), albumin (ALB), glucose (GLU),cholesterol (CHOL), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), very low-densitylipoproteins cholesterol (VLDL-c), and superoxide dismutase (SOD) were noticeably increased in ratsadministered fenitrothion. However, the level of serum high-density lipoprotein cholesterol (HDL-c) andglutathione (GSH) were markedly decreased. It was found that fish oil and evening primrose oil decreased thephysiological unsettling influences initiated by fenitrothion. Moreover, the antioxidant properties of these oilssupported the bioactive roles of its defensive impacts on fenitrothion toxicity. Finally, the present findings suggestthat these oils may be utilized as preventive components against the toxicity of fenitrothion because of theirantioxidant properties.