Microsponge: An Innovative Strategy For Drug Delivery System

ABSTRACT

Microsponge technology has been introduced in topical drug products to facilitatethe controlled release of active drug into the skin in order to reduce systemic exposure andminimize local cutaneous reactions to active drugs. Microsponge consists of macroporousbeads, typically 10-25µ in diameter, loaded with active agent. When applied to the skin, themicrosponge releases its active ingredients on a time mode and also in response to otherstimuli. Microsponge drug delivery technology holds a great promise for reaching the goal ofcontrolled and site-specific drug delivery and hence, has attracted wide attention ofresearchers. This article presents a broad review of Microsponges delivery system discussingthe principles and preparation methods. Appropriate analytical techniques for characterizationof Microsponges like Particle size and its distribution, surface morphology, porosity, densityare covered. These microsponges are used in the sunscreens, creams, ointments, over-thecounter skin care preparations, which are meant for topical application. Microsponge drugdelivery can provide increased efficacy for topically active agents with enhanced safety,extended product stability and improved aesthetic properties in an efficient and novel manner.They are mostly used for topical use and have recently been used for oral administration