Evaluation of Fibrinolytic Efficacy of Averrhoa Bilimbi Linn. by Using Euglobulin Lysis Time Method
Article
| IMSEAR
| ID: sea-205111
ABSTRACT
Background:
An impaired fibrinolytic function had been reported in subjects suffering from venous thrombosis. The euglobulin clot lysis time is a test that reflects the overall fibrinolytic activity of plasma.Objective:
To evaluate the fibrinolytic efficacy of ethanolic extract of Averrhoa bilimbi Linn. leaves by using Euglobulin lysis time method.Methods:
Rats were divided into 3 groups. Each group was containing 6 rats. Group I received vehicle (control) 0.9% saline solution; Group II received 25 mg/kg ethanolic extract leaves of Averrhoa bilimbi Linn; Group III received 50 mg/kg ethanolic extract leaves of Averrhoa bilimbi Linn. Blood (1.8 ml) was removed with a plastic syringe containing 0.2 ml 3.8% sodium citrate solution. The time interval between the addition of thrombin and the complete lysis of the clots was measured. The lysis time (min) was determined.Conclusion:
We observed ethanolic extract of Averrhoa bilimbi Linn. leaves may increase the activators of the fibrinolysis. Further investigation is warranted.
Full text:
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Index:
IMSEAR (South-East Asia)
Year:
2019
Type:
Article
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