Association of polymorphisms of xeroderma pigmentosum complementation group D gene with cervical cancer in Maharashtrian population: A case-control study
Article
| IMSEAR
| ID: sea-205377
ABSTRACT
Background:
Maharashtrian population is at the risk of cervical cancer (CC) and is not subjected to investigate the cancer susceptibility in association with genetic determinants.Objectives:
This study was aimed to evaluate the association of single nucleotide polymorphisms (SNPs) in DNA repair gene xeroderma pigmentosum complementation group D (XPD) with CC risk from rural Maharashtra. Materials andMethods:
We used polymerase chain reaction and-restriction fragment length polymorphism to analyze SNPs in XPD gene from 350 patients with CC and 400 age and sex-matched disease-free controls.Results:
The results indicated no significant difference in the genotype distribution between CC patients and controls for the XPD gene at codon 156 of exon 6 and codon 751 of exon 23, but the results showed that allele frequencies of XPD Asn 312 of codon 312 of exon 10 (odds ratio = 0.31; 95% confidence intervals = [0.16–0.63]; P = <0.001) genotype showed negative association with CC risk.Conclusion:
This study indicated the role of XPD (cd312) in modifying genetic susceptibility of an individual to CC in Maharashtrian patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Observational study
/
Risk factors
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS