Separation And Analysis Of Amlodipine/Benazepril Combination In Capsules By A Novel Ion Pair Liquid Chromatography
Int J Pharm Pharm Sci
;
2019 Jan; 11(1): 107-112
Article
| IMSEAR
| ID: sea-205821
ABSTRACT
Objective:
The objective of this study was to develop and validate a novel ion-pair liquid chromatography method, in order to separate and assay of amlodipine/benazepril combination in capsules. This method was a fast, practical and additional choice in quality control laboratories.Methods:
The chromatographic conditions comprised of a classical C18-type stationary phase (250 × 4.6 mm, 5μ), with a mobile phase consisting of 45% of 10-3 M of cetrimide and 55% acetonitrile. The flow rate was 1 ml/min; the detection wavelength was at 242 nm, under ambient temperature.Results:
The method was validated for linearity with correlation coefficients very close to one, the accuracy with mean recovery values between 95.0-105.0%, precision with relative standard deviations of the calculated concentrations less than 5.0% and specificity in the presence of degradation products and excipients.Conclusion:
The results presented in this paper showed that the developed method was fast and applicable, for the separation and determination of amlodipine/benazepril combination in capsules.
Full text:
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Index:
IMSEAR (South-East Asia)
Journal:
Int J Pharm Pharm Sci
Year:
2019
Type:
Article
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