A Preliminary Investigation Of Htr1a Gene Expression Levels In Autism Spectrum Disorders
Int J Pharm Pharm Sci
;
2019 Aug; 11(8): 1-3
Article
| IMSEAR
| ID: sea-205926
ABSTRACT
Objective:
This study was conducted to explore the expression levels of HTR1A gene in a sample of Egyptian autistic children.Methods:
Thirty autistic patients (18 boys, 12 girls) and 20 controls were enrolled in the study. From each child, we isolated RNA samples from whole blood. Quantitative Real-Time PCR (qRT-PCR) was used to measure the gene expressions of HTR1A and normalized to the house keeping gene, beta-actin.Results:
The HTR1A gene expression of healthy controls and ASD subjects were varied significantly (p =0.0062). As compared to control healthy subjects, the HTR1A expressions were greatly reduced in samples of ASD.Conclusion:
HTR1A gene expression level is a candidate gene for further studies to explore its potential roles in ASD related pathways.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Journal:
Int J Pharm Pharm Sci
Year:
2019
Type:
Article
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