Formulation And Evaluation Of Orodispersible Tablets Of Lamotrigineusing Discrete Super Disintegrants And Coprocessed Excipients
Int J Pharm Pharm Sci
;
2020 Jun; 12(6): 25-27
Article
| IMSEAR
| ID: sea-206104
ABSTRACT
Objective:
The present study was designed to formulate and evaluate the orodispersible tablets of lamotrigine after enhancing its solubility.Methods:
Lamotrigine was made into an inclusion complex with eudragit E 100 my kneading and mass extrusion method and later this mixture is compressed into orodispersible tablet using various super disintegrants and co-processed excipients to reduce the disintegration time for providing prompt action through rapid drug release.Results:
Lamotrigine ODTs containing F-melt (F1-3%, F2-5%) dispersed in lesser time of (9±0.11) and (21±0.58) compared to formulations with polyplasdone XL-10 and primellose as super disintegrants respectively with F1 showing short wetting time. The water absorption was also was found to be more for formulation with 3% F-Melt.Conclusion:
Lamotrigine orodispersible tablets were prepared by direct compression technique by using 3% and 5% of three super disintegrants (f-melt, primellose and polyplasdone XL-10). Disintegration time of F1 (3% f-melt) formulation was found to be least (7 sec).
Full text:
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Index:
IMSEAR (South-East Asia)
Journal:
Int J Pharm Pharm Sci
Year:
2020
Type:
Article
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