Effect of hydroxyurea on foetal haemoglobin in myeloproliferative & myelodysplastic syndromes.

Advani, S H; Venugopal, P; Charak, B S; Das Gupta, A; Mazumdar, A T; Gopal, R; Nair, C N; Saikia, T K; Nadkarni, K S; Kurkure, P A

Advani, S H; Venugopal, P; Charak, B S; Das Gupta, A; Mazumdar, A T; Gopal, R; Nair, C N; Saikia, T K; Nadkarni, K S; Kurkure, P A.

Article in English | IMSEAR | ID: sea-20895

ABSTRACT

ABSTRACT

The effect of hydroxyurea on foetal haemoglobin (HbF) levels was evaluated in 36 patients of myeloproliferative and myelodysplastic disorders. In 17 (47.2%) patients, HbF levels increased from 1.40 +/- 1.17 to 3.03 +/- 1.97 per cent after 4 wk therapy with hydroxyurea. In the responders this increase was highly significant (P less than 0.001). The rise in the HbF levels after hydroxyurea therapy was significant in patients with chronic myeloid leukaemia but not in the other groups.

Subject(s)

Adolescent; Adult; Aged; Child; Female; Fetal Hemoglobin/analysis; Humans; Hydroxyurea/pharmacology; Male; Middle Aged; Myelodysplastic Syndromes/blood; Myeloproliferative Disorders/blood

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Myelodysplastic Syndromes / Aged / Female / Humans / Male / Fetal Hemoglobin / Child / Adolescent / Adult / Hydroxyurea Language: English Year: 1990 Type: Article

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