A Study of Correlation of Clinical Variables with Presenting Stage and Type of Endometrial Cancer at a Tertiary Care Hospital - A Retrospective Study

ABSTRACT

Introduction: The prevalence of gynecological cancers has been increasing in the Asian population. With the recent changingtrend in lifestyle and reproductive profile of women, the number of cases being diagnosed with endometrial cancer is increasing.Aim: The aim of this study is to evaluate the correlation of various clinical risk factors of endometrial carcinoma on thehistopathology and presenting stage of the disease.Materials and Methods: A hospital-based, retrospective study included 100 patients of endometrial carcinoma presented atthe Institute of Obstetrics and Gynaecology, Chennai, India, between January 2016 and June 2019. The correlation of age(≤40 years and >40 years), parity status (parous and nulliparous), menstrual status (premenopause and postmenopause),diabetes, hypertension, duration of complaint (≤6 months and >6 months), and body mass index (BMI) with the stage of thedisease (clinical/radiological and pathological stages) and histological class was analyzed.Results: The mean age of patients was 56.4 ± 11.3 years. Among the 100 patients, a total of 62 (63.6%) patients had presentedwith clinical/radiological stage-I, of which 6 patients had defaulted for treatment and 6 patients had the stage-IV disease. Of the88 patients who underwent staging laparotomy, 59 (67%) patients had pathological stage-I carcinoma and 3, 18, and 8 patientspresented in stage II, III, and IV disease, respectively. Histopathological evaluation revealed endometrioid adenocarcinomaas the most common type, in 79 patients (79%). No significant correlation of any of the risk factors on clinical/radiological,pathological as well as on histopathology was observed.Conclusion: The study did not state the statistically significant association of age, parity status, menopause, diabetes,hypertension, BMI, and the duration of complaints with the histological class of endometrial carcinoma and presenting clinicaland pathological stages of endometrial carcinoma.