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A Prospective Study on Concurrent Chemoradiation in Inoperable Carcinomas Esophagus
Article | IMSEAR | ID: sea-209334
ABSTRACT

introduction:

Despite many advances in both surgery and radiotherapy, the treatment of esophageal cancer remains a challenge for both surgeons and oncologists. The treatment of choice for patients with carcinoma esophagus is controversial. Recent studies have suggested that combined chemotherapy and radiation therapy may result in improved survival.

Aim:

The aim of our study was to analyze the role of concurrent chemoradiation in inoperable carcinomas esophagus. Materials and

Methods:

This single-arm prospective study was conducted in the Department of Radiotherapy, Thanjavur Medical College Hospital from August 2018 to August 2019 to analyze the role of concurrent chemoradiation in inoperable carcinomas esophagus. A total of 26 cases of inoperable cases of carcinoma esophagus were treated with once-weekly cisplatin 30 mg/ m2 along with radiotherapy 60 Gy in 30 fractions in 6 weeks on telecobalt machine.

Results:

Of 26 patients 16 patients were males, 10 patients were females, 17 patients had age <60 years, 9 patients had age above 61 years, 22 patients had squamous cell carcinoma, 4 patients had adenocarcinoma, 4 patients had lesion in upper part of esophagus, 14 patients had lesion in middle part, 8 patients had lesion in lower part, 4 patients had tumor dimension <5 cm, 22 patients had dimension >5.1 cm, 2 patients had tumor stage T1, 22 patients had T2, 2 patients had T3, 1 patient had Nx, 21 patients had No, 4 patients had N1, 15 patients had mild dysphagia, 8 patients had moderate dysphagia, 3 patients had severe dysphagia1 patients had diarrhea, 1 patient had fatigue, 4 patients had leukopenia, and 1 patient had neutropenia.

Conclusion:

Combined modality therapy plays a significant role in the treatment of patients with carcinoma esophagus. Concurrent chemoradiation is a superior treatment in inoperable carcinoma esophagus in terms of local control and survival. Hence, concurrent chemoradiation can also be tried in early cases and surgical morbidity survival and quality of life can be improved.

Full text: Available Index: IMSEAR (South-East Asia) Type of study: Observational study Year: 2020 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Type of study: Observational study Year: 2020 Type: Article