The Impact of Insecticide-treated Bed Nets on Parity and Malaria Sporozoite Infectivity of Anopheles Species in Kamuli District, Uganda
Article
| IMSEAR
| ID: sea-209670
ABSTRACT
Background:
Themainobjectiveoftreatingbednetswithinsecticidesistoaffectthemeanlongevityofthemainvectorpopulation,andconsequentlythevectordensityandsporozoiterates.Objective:
Thisstudyaimedatestablishingtheimpactofinsecticide-treatedbednets(ITNs)onthelongevityandabilitytotransmitmalariasporozoitesbythevectorspeciesasanassessmentofeffectivenessoftheITNinterventioninKamulidistrict,Uganda.Methods:
Indoorhuman-bitingmosquitoesweretrappedinthreerandomlyselectedhousesintwoseparatenightsusingbattery-operatedCDClighttrapsinbothintervention(withITNs)andnon-interventionvillages(withoutITNs).Thefemaleanophelinesweredissectedandtheirparityrates andPlasmodiumfalciparumsporozoitepositivitycomparedbetweenthetwozones.AsporozoiteEnzyme-LinkedImmunoSorbentAssay,ELISA,wasusedtodetectthepresenceofP.falciparumsporozoitesintheparousvectorsinbothzones.TheparityandP.falciparumsporozoiteinfectivitywerecomparedbetweenthetwozonesusingtheKruskal-WallisranksumtestoftheR-Statisticssoftware.Results:
Outofthe166Anophelesmosquitoesdissected,37.3%(19outof51)and53.9%(62outof115)wereparousintheinterventionandnon-interventionzones,respectively,indicatingthatparityofthemosquitoeswashigherinthenon-intervention(p=0.005).Infectivityofthevectorsinthenon-interventionexceededthatintheinterventionzone(p=0.032),withactivesporozoitetransmissionobservedbeforeandafterbedtimeinthenon-interventionzone.Conclusion:
ResultsshowedthatITNshadimpactedonthesurvivalandconsequentlythedensityoftheoldermalariavectors,andontheirabilitytotransmitPlasmodiumsporozoites.Thiscallsforintensificationofuseofthiseffectivemalariacontrolstrategy,coupledwithbehaviouralchangecommunicationsstrategytopromotecorrectuse,aswellasuseofotherinterventionslikerepellentstoprovideadditionalprotectionespeciallybeforeandafterbedtime
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Index:
IMSEAR (South-East Asia)
Year:
2020
Type:
Article
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