Low dose and subchronic Aroclor 1254 induced histopathological changes in mice kidney

ABSTRACT

Present communication reports the low dose and subchronic duration-dependent histopathological changes afterexposure to Aroclor 1254 in the kidney tissue of Swiss albino mice. Polychlorinated biphenyls (PCBs) like Aroclor1254 congeners accumulate in tissues rich in lipids and remain inside for a long time, affecting the functionality of thecells in direct and indirect ways. The most commonly observed effects were skin ailments such as chloracne, rashes,and effects on kidney functions. Animal studies indicated that PCBs could affect the functionality of the kidney,thyroid, immune, and endocrine systems. Separate groups of mice were subjected to a daily oral dose of 0.1 mg/kgbody weight (BW)/day and 1 mg/kg BW/day Aroclor 1254, dissolved in corn oil, for four subacute exposure durations(7, 14, 21, and 28 days). Control groups were received only the corn oil (vehicle). Results revealed mainly exposureduration-dependent histopathological lesions such as dilation of the tubular cells, fragmentation of cytoplasm andloss of nuclear materials, formation of large vacuoles inside the cells, and necrosis even at very low doses of Aroclorintoxication. The present study reports predominantly exposure duration-dependent histopathological effects ofAroclor 1254 in the kidney tissue of mice. The study suggested that the subacute exposure to low doses of Aroclor1254 could cause significant irreparable structural deformities in the renal cells of the kidney tissue. Results alsoshowed that renal tubular cells were more affected showing severe necrosis