Biochemical and liver histological changes in rats exposed to sub-lethal dose of Uproot-pesticide and the protective potentials of nutritional supplements

ABSTRACT

This study determined the therapeutic potentials of vitamin C, glutathione, and garlic on the hepatic andhistological changes induced by uproot-pesticide on albino Wistar rats. All animal groups (except normalcontrol) received intraperitoneally 50 mg/kg body weight of uproot-pesticide (a commercially formulatedglyphosate-based herbicide) on alternate days and daily oral administration (except Uproot control) of 20 mg/kg body weight of glutathione, vitamin C, and garlic as nutritional supplements singly and in combination for28 days. Liver function and oxidative stress parameters of the liver were determined using blood and liversamples. Histological studies were done on the liver tissue. The values obtained showed significant variationof measured parameters in Uproot control compared to groups administered nutritional supplements and thecontrol. These variations indicated oxidative liver damage and significant therapeutic potential of the nutritionalsupplements. Other observed significant and non-significant changes were discussed.