Synthesis, in silico study and in vitro anti-microbial evaluation of some new N-benzoyl-N'-[2-(4-chloro-phenoxy)-acetyl]-hydrazides analogs

ABSTRACT

In bacterial resistance duty, the prompt increase against existent anti-microbial drugs is a challenging universal healthproblem. Bacteria represent a highly significant threat globally to healthcare-associated infections, also responsiblefor the majority of hospital infections, which leads to an increase in the mortality and burden of worldwide healthcareduty. In this investigation, we reported the synthesis novel substitutes of phenoxy hydrazide analogs (6a–f) andhave been screened for in vitro anti-bacterial and anti-fungal activities to determine the inhibition zone by using thepaper disk agar diffusion technique and broth dilution to evaluate the minimum inhibitory concentration values. Thestructure–activity relationship suggest that among the series (6a–f), compounds (6e) with two chloro groups and (6f)with four fluoro groups showed good inhibition against pathogenic microbes. Furthermore, these results were alsoconfirmed by the in silico study. Based on this studies, there are a scopes of developing compounds (6e) and (6f) intopotent anti-microbial drugs in the near future.